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Cystic Fibrosis and the Reproductive System

How does CF affect the reproductive system?

Children with cystic fibrosis (CF) have a problem with how the cell protein CFTR (cystic fibrosis transmembrane conductance regulator) works. CFTR controls the flow of water and certain salts in and out of the body's cells. As the movement of salt and water in and out of cells is altered, mucus becomes thickened.

In the reproductive system, the thickened secretions can cause blockages. These can affect how the sex organs develop and work.

For most men with CF, the tube (vas deferens) that carries sperm to the penis does not develop. This is called congenital bilateral absence of the vas deferens (CBAVD). In men with CBAVD, even though the vas deferens is missing, the sperm are not. In fact, 90% of men with CF and CBAVD have normal sperm production. This means that most men with CF can conceive biological children. A reproductive specialist (urologist) can use tests to find out a person's reproductive status.

Women also have an increase in thick cervical mucus. This may make it harder for them to get pregnant. But it doesn't affect sex drive or performance in either women or men.  

Symptoms that may be present due to CF’s effects on the reproductive system include:

  • Delayed sexual development

  • Absence or stopping of menstruation

  • Irregular menstrual periods

  • Inflammation of the cervix

  • Infertility or sterility

People with CF are living longer and healthier lives. Many now can think about having children.

Talk with your CF healthcare team if you are thinking about parenting or having a baby.

Online Medical Reviewer: Daphne Pierce-Smith RN MSN
Online Medical Reviewer: David A Kaufman MD
Online Medical Reviewer: Marianne Fraser MSN RN
Date Last Reviewed: 8/1/2021
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