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Isoleucine

Other name(s):

a-amino-b-methyl-n-valeric acid

Unsubstantiated claims

There may be benefits that have not yet been proven through research.

Isoleucine is an essential amino acid. It may help how hemoglobin is made. This is the oxygen-carrying pigment inside of red blood cells. It may help control blood sugar. It may also boost energy and endurance. It’s also said to help speed healing of injured muscles. Isoleucine may also help muscle development and lean body mass. 

Recommended intake

Amino acids (AAs) can be taken as single AAs or in AA combinations. They also come as part of multi-vitamins, proteins, and food supplements. The forms include tablets, fluids, and powders.

If you eat enough protein in your diet, you get all of the amino acids you need.

There are no conditions that increase how much isoleucine you need.

Side effects, toxicity, and interactions

Using a single amino acid supplement may lead to negative nitrogen balance. This can lessen how well your metabolism works. It can also make your kidneys work harder. In children, taking single amino acid supplements may also cause growth problems.

You should not take high doses of single amino acids for long periods of time.

These people shouldn’t take isoleucine:

  • People who are taking leucine and valine

  • Women who are pregnant or breastfeeding

  • People with maple syrup urine disease (MSUD) or cystinuria

Online Medical Reviewer: Diane Horowitz MD
Online Medical Reviewer: Raymond Kent Turley BSN MSN RN
Online Medical Reviewer: Rita Sather RN
Date Last Reviewed: 1/1/2019
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